5/1/2025
Last update
5/1/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 47 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Advanced 40+ Acidophilus 1.5 billion CFUproviding:Lactobacillus. acidophilus, (LA-5®)300 million CFULactobacillus rhamnosus GG (LGG®)300 million CFULactobacillus paracasei (L. CASEI 431®)300 million CFU Bifidobacterium lactis (BB-12®)300 million CFUStreptococcus thermophilus, (TH-4®)300 million CFU
2.4 mg
**
Top Medical Research Studies
9
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Read More
9
Lactobacillus drink benefits IBS-C
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Read More
9
This study looked into the effects of two probiotic strains, DDS-1 and UABla-12, on alleviating abdominal pain and other IBS symptoms.
We observed that participants taking these probiotics experienced notable reductions in pain severity and overall symptom scores compared to those receiving a placebo.
Specifically, both probiotic groups reported improved bowel habits and stool consistency, enhancing quality of life for adults facing IBS.
Overall, the results suggest that these probiotic strains can be beneficial for managing symptoms of irritable bowel syndrome.
We observed that participants taking these probiotics experienced notable reductions in pain severity and overall symptom scores compared to those receiving a placebo.
Specifically, both probiotic groups reported improved bowel habits and stool consistency, enhancing quality of life for adults facing IBS.
Overall, the results suggest that these probiotic strains can be beneficial for managing symptoms of irritable bowel syndrome.
Read More
Most Useful Reviews
9
Convenient effectiveness
4 people found this helpful
This is the finest quality product I have tried among all probiotics, even better than those from pharmacies! It's highly convenient for travel, as it doesn't require refrigeration. It significantly assists me with my irritable bowel syndrome.
Read More
7.5
Highly recommended
1 people found this helpful
A fantastic product that's easy to swallow and reasonably sized. It aids my digestive system exceptionally well, helping with constipation and bowel movements without causing dependency or leaving an aftertaste. The quality is excellent, and I highly recommend it.
Read More
6
Improved constipation
This probiotic may help due to the beneficial gut bacteria it contains for managing bowel movements and digestion. While I'm unsure of its efficacy for others, I noticed improvements in my constipation after using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 47 Researches
7.3
- All Researches
9.5
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9
Lactobacillus drink benefits IBS-C
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Read More
9
This study looked into the effects of two probiotic strains, DDS-1 and UABla-12, on alleviating abdominal pain and other IBS symptoms.
We observed that participants taking these probiotics experienced notable reductions in pain severity and overall symptom scores compared to those receiving a placebo.
Specifically, both probiotic groups reported improved bowel habits and stool consistency, enhancing quality of life for adults facing IBS.
Overall, the results suggest that these probiotic strains can be beneficial for managing symptoms of irritable bowel syndrome.
We observed that participants taking these probiotics experienced notable reductions in pain severity and overall symptom scores compared to those receiving a placebo.
Specifically, both probiotic groups reported improved bowel habits and stool consistency, enhancing quality of life for adults facing IBS.
Overall, the results suggest that these probiotic strains can be beneficial for managing symptoms of irritable bowel syndrome.
Read More
9
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Convenient effectiveness
4 people found this helpful
This is the finest quality product I have tried among all probiotics, even better than those from pharmacies! It's highly convenient for travel, as it doesn't require refrigeration. It significantly assists me with my irritable bowel syndrome.
Read More
7.5
Highly recommended
1 people found this helpful
A fantastic product that's easy to swallow and reasonably sized. It aids my digestive system exceptionally well, helping with constipation and bowel movements without causing dependency or leaving an aftertaste. The quality is excellent, and I highly recommend it.
Read More
6
Improved constipation
This probiotic may help due to the beneficial gut bacteria it contains for managing bowel movements and digestion. While I'm unsure of its efficacy for others, I noticed improvements in my constipation after using it.
Read More
2
No improvements
I suffer from constipation and have been trying various remedies to enhance my bowel movements. After a month of taking this product, I noticed no changes. Unfortunately, it didn’t seem compatible with my intestines.
Read More
Frequently Asked Questions
9
Convenient effectiveness
4 people found this helpful
This is the finest quality product I have tried among all probiotics, even better than those from pharmacies! It's highly convenient for travel, as it doesn't require refrigeration. It significantly assists me with my irritable bowel syndrome.
6
Improved constipation
This probiotic may help due to the beneficial gut bacteria it contains for managing bowel movements and digestion. While I'm unsure of its efficacy for others, I noticed improvements in my constipation after using it.
2
No improvements
I suffer from constipation and have been trying various remedies to enhance my bowel movements. After a month of taking this product, I noticed no changes. Unfortunately, it didn’t seem compatible with my intestines.
7.5
Highly recommended
1 people found this helpful
A fantastic product that's easy to swallow and reasonably sized. It aids my digestive system exceptionally well, helping with constipation and bowel movements without causing dependency or leaving an aftertaste. The quality is excellent, and I highly recommend it.
9.5
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
8
Lactobacillus acidophilus improves IBS
We aimed to investigate how well the probiotic Neobiotic Lactobalance®, which contains Lactobacillus acidophilus, can relieve symptoms of irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea. Over 21 days, 54 participants took one capsule daily. With clear signs of symptom relief, patients reported significant improvements in diarrhea, abdominal pain, and dyspeptic symptoms. Our findings showed a normalization of the intestinal microbiota, indicating that Lactobacillus acidophilus and other included probiotics may effectively support digestive health for those struggling with these conditions.
7
We examined how different gut bacteria in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) responded to probiotic treatment. In our study, patients were split into a probiotic group and a placebo group, with fecal samples collected before and after eight weeks.
Although we found changes in fecal bacteria due to probiotics, the results indicated that not all patients benefited equally. We noted specific gut bacteria correlated with symptom relief, pointing to potential indicators for predicting who might not respond to probiotics.
Although we found changes in fecal bacteria due to probiotics, the results indicated that not all patients benefited equally. We noted specific gut bacteria correlated with symptom relief, pointing to potential indicators for predicting who might not respond to probiotics.
9
This study looked into the effects of two probiotic strains, DDS-1 and UABla-12, on alleviating abdominal pain and other IBS symptoms.
We observed that participants taking these probiotics experienced notable reductions in pain severity and overall symptom scores compared to those receiving a placebo.
Specifically, both probiotic groups reported improved bowel habits and stool consistency, enhancing quality of life for adults facing IBS.
Overall, the results suggest that these probiotic strains can be beneficial for managing symptoms of irritable bowel syndrome.
We observed that participants taking these probiotics experienced notable reductions in pain severity and overall symptom scores compared to those receiving a placebo.
Specifically, both probiotic groups reported improved bowel habits and stool consistency, enhancing quality of life for adults facing IBS.
Overall, the results suggest that these probiotic strains can be beneficial for managing symptoms of irritable bowel syndrome.
References
- Sarkawi M, Raja Ali RA, Abdul Wahab N, Abdul Rathi ND, Mokhtar NM. A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. Sci Rep. 2024;14:9478. 10.1038/s41598-024-60029-2
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;72:233.
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;73:233.
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. 10.5056/jnm23036
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. 10.33029/0042-8833-2023-92-4-92-103
- Cocetta V, Giacomini I, Tinazzi M, Berretta M, Quagliariello V, et al. Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins. Minerva Pediatr (Torino). 2023. 10.23736/S2724-5276.23.07128-8
- Shin SY, Park S, Moon JM, Kim K, Kim JW, et al. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial. J Neurogastroenterol Motil. 2022;28:642. 10.5056/jnm21202
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. 10.51821/84.4.009
- Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. 10.3390/nu12071999
- Martoni CJ, Srivastava S, Leyer GJ. DDS-1 and UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020;12. 10.3390/nu12020363
- Sadrin S, Sennoune S, Gout B, Marque S, Moreau J, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis. 2020;52:534. 10.1016/j.dld.2019.12.009
- Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, et al. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Benef Microbes. 2018;9:697. 10.3920/BM2017.0105
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. 10.1007/s12602-018-9401-3
- Bogovič Matijašić B, Obermajer T, Lipoglavšek L, Sernel T, Locatelli I, et al. Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial. J Dairy Sci. 2016;99:5008. 10.3168/jds.2015-10743
- Yoon H, Park YS, Lee DH, Seo JG, Shin CM, et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr. 2015;57:129. 10.3164/jcbn.15-14
- Yoon JS, Sohn W, Lee OY, Lee SP, Lee KN, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol. 2014;29:52. 10.1111/jgh.12322
- Barbaro MR, Bianco F, Cremon C, Marasco G, Stanghellini V, et al. A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1. Int J Mol Sci. 2025;26. 10.3390/ijms26062656
- Gąsiorowska A, Romanowski M, Walecka-Kapica E, Kaczka A, Chojnacki C, et al. Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Med. 2024;14. 10.3390/jcm14010006
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. 10.1038/s41598-024-72887-x
- Zhang L, Ni X, Jiang M, Du M, Zhang S, et al. Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome. Microorganisms. 2024;12. 10.3390/microorganisms12061081
- Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. 10.1111/eci.13201
- Ding FCL, Karkhaneh M, Zorzela L, Jou H, Vohra S. Probiotics for paediatric functional abdominal pain disorders: A rapid review. Paediatr Child Health. 2019;24:383. 10.1093/pch/pxz036
- Nocerino R, Di Costanzo M, Bedogni G, Cosenza L, Maddalena Y, et al. Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy. J Pediatr. 2019;213:137. 10.1016/j.jpeds.2019.06.004
- Hojsak I. Probiotics in Functional Gastrointestinal Disorders. Adv Exp Med Biol. 2019;1125:121. 10.1007/5584_2018_321
- Han X, Lee A, Huang S, Gao J, Spence JR, et al. Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes. 2019;10:59. 10.1080/19490976.2018.1479625
- Wegh CAM, Benninga MA, Tabbers MM. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S10. 10.1097/MCG.0000000000001054
- Darbaky Y, Evrard B, Patrier S, Falenta J, Garcin S, et al. Oral probiotic treatment of Lactobacillus rhamnosus Lcr35 prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress. J Appl Microbiol. 2017;122:188. 10.1111/jam.13320
- Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17:199. 10.1007/s40272-015-0124-6
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. 10.1007/s00394-024-03398-8
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. 10.3390/jcm12144838
- Boonma P, Shapiro JM, Hollister EB, Badu S, Wu Q, et al. Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome. Front Pain Res (Lausanne). 2021;2:691689. 10.3389/fpain.2021.691689
- Xu H, Ma C, Zhao F, Chen P, Liu Y, et al. Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable bowel syndrome. Eur J Nutr. 2021;60:2553. 10.1007/s00394-020-02437-4
- Szajewska H, Hojsak I. Health benefits of GG and subspecies BB-12 in children. Postgrad Med. 2020;132:441. 10.1080/00325481.2020.1731214
- Le Nevé B, Derrien M, Tap J, Brazeilles R, Cools Portier S, et al. Fasting breath H2 and gut microbiota metabolic potential are associated with the response to a fermented milk product in irritable bowel syndrome. PLoS One. 2019;14:e0214273. 10.1371/journal.pone.0214273
- Baştürk A, Artan R, Yılmaz A. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2016;27:439. 10.5152/tjg.2016.16301
- Eskesen D, Jespersen L, Michelsen B, Whorwell PJ, Müller-Lissner S, et al. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015;114:1638. 10.1017/S0007114515003347
- Veiga P, Pons N, Agrawal A, Oozeer R, Guyonnet D, et al. Changes of the human gut microbiome induced by a fermented milk product. Sci Rep. 2014;4:6328. 10.1038/srep06328
- Yoon JY, Cha JM, Oh JK, Tan PL, Kim SH, et al. Probiotics Ameliorate Stool Consistency in Patients with Chronic Constipation: A Randomized, Double-Blind, Placebo-Controlled Study. Dig Dis Sci. 2018;63:2754. 10.1007/s10620-018-5139-8
- Ortiz-Lucas M, Tobías A, Saz P, Sebastián JJ. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Rev Esp Enferm Dig. 2013;105:19.
- Ki Cha B, Mun Jung S, Hwan Choi C, Song ID, Woong Lee H, et al. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol. 2012;46:220. 10.1097/MCG.0b013e31823712b1
- Zeng J, Li YQ, Zuo XL, Zhen YB, Yang J, et al. Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2008;28:994. 10.1111/j.1365-2036.2008.03818.x
- Drouault-Holowacz S, Bieuvelet S, Burckel A, Cazaubiel M, Dray X, et al. A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome. Gastroenterol Clin Biol. 2008;32:147. 10.1016/j.gcb.2007.06.001
- Astegiano M, Pellicano R, Terzi E, Simondi D, Rizzetto M. Treatment of irritable bowel syndrome. A case control experience. Minerva Gastroenterol Dietol. 2006;52:359.
- Brigidi P, Vitali B, Swennen E, Bazzocchi G, Matteuzzi D. Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. Res Microbiol. 2001;152:735.
- Gomes P, Laroute V, Beaufrand C, Bézirard V, Aubry N, et al. Postbiotic potential of Lactococcus lactis CNCM I-5388 in alleviating visceral pain in female rat through GABA production: The innovative concept of the "active-GAD bag". FASEB J. 2025;39:e70383. 10.1096/fj.202401125RR
- Gomes P, Laroute V, Beaufrand C, Daveran-Mingot ML, Aubry N, et al. Lactococcus lactis CNCM I-5388 versus NCDO2118 by its GABA hyperproduction ability, counteracts faster stress-induced intestinal hypersensitivity in rats. FASEB J. 2023;37:e23264. 10.1096/fj.202301588R
- Laroute V, Beaufrand C, Gomes P, Nouaille S, Tondereau V, et al. NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract. Elife. 2022;11. 10.7554/eLife.77100
